7-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole → 7-chloro-3-(piperidin-4-yl)-1H-indole

HRID 481642노트

반응식

HRID 481642 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[C:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH:16]=1.[H][H]>[Pt]=O.C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[CH:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1

참가 물질

5

반응물 2

HCID 185458497-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 120720367-chloro-3-(piperidin-4-yl)-1H-indole

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

7-Chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (2.0 g, 8.62 mmol) and 0.5 g of platinum oxide were added to 100 mL of ethanol and the mixture was shaken under about 50 psi hydrogen at about ambient temperature for about a day. The mixture was filtered and the filtrate concentrated to yield a solid comprising the desired product. Yield 1.64 g (81%) as a yellow solid. FDMS m/e=234 (M+).

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated

출처 및 근거

ORD 기록
ord-b2ea792f0c8a470ebff20e1fab7f00cb
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789402

반응 노트

불러오는 중…