Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-(2-hydroxy-5-bromophenyl)-3,3-dimethylbutyramide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| 반응물 | 2-Amino-4-Bromophenol | HCID 351840 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | N-(2-hydroxy-5-bromophenyl)-3,3-dimethylbutyramide | HCID 22742126 | 31.5% |
반응 단계
A solution of tert-butylacetyl chloride (2.7 g, 0.020 mol) in diethyl ether (20 ml) was added dropwise to a solution of 2-amino-4bromophenol (3.8 g, 0.020 mol) and triethylamine (2.1 g, 0.020 mol) in diethyl ether (160 ml) and the mixture was stirred at room temperature for 3 hours. The mixture was filtered and the filtrate was evaporated in vacuo. Purification by flash column chromatography on silica gel, eluting initially with ethyl acetate:dichloromethane 1.5:98.5 and then with ethyl acetate:dichloromethane 2.5:97.5, gave N-(2-hydroxy-5-bromophenyl)-3,3-dimethylbutyramide (1.8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06703347B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-a4dae2ba05c94e56acd37a42b6eece85 |
| 출처 메모 | uspto-grants-2004_03 |