Methanol → Methyl 2-(4-fluoro-3-nitrophenyl)acetate

HRID 48169노트

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HRID 48169 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].S(=O)(=O)(O)O.[CH3:20]O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:20])=[O:10])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 111272614-Fluoro-3-nitrophenylacetic acid

생성물 1

HCID 22742120Methyl 2-(4-fluoro-3-nitrophenyl)acetate

실험 절차

4-Fluoro-3-nitrophenylacetic acid (31.0 g, 0.156 mol) was added to a mixture of concentrated sulfuric acid (1.6 ml) and methanol (160 ml) and the mixture was stirred for 3 days at room temperature. Most of the solvent was removed in vacuo and the residue was partitioned between diethyl ether and water. The organic phase was washed with saturated aqueous sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered and the filtrate was evaporated in vacuo to give methyl 4-fluoro-3-nitrophenylacetate (27.2 g) as a yellow oil.

후처리

  1. customMost of the solvent was removed in vacuo
  2. customthe residue was partitioned between diethyl ether and water
  3. washThe organic phase was washed with saturated aqueous sodium bicarbonate solution and brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-cda7c95d3a9d45f4a7273c50490ba941
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703347B2

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