Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → Enalapril Maleate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | L-Proline | HCID 145742 | — |
| 반응물 | N-[1(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine | HCID 5702571 | — |
| 생성물 | Enalapril Maleate | HCID 5388961 | 77% |
반응 단계
In ES patent 2,004,804 the preparation of carboxyalkyldipeptides useful as ACE inhibitors is disclosed. N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine is treated with 1,1-carbonyldiimidazole in EtOAc and subsequently with L-proline and enalapril maleate is obtained with a 77% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05789597 |
| 출처 데이터셋 | uspto-grants-1998_08 |
| ORD ID | ord-144515cf7c904447a446d2e6c12d553b |
| 출처 메모 | uspto-grants-1998_08 |