Water → HCID 19067073, 화합물

HRID 481763노트

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HRID 481763 반응식
I[CH:2]1[C:8](=[O:9])[NH:7][C:6]2[N:10]=[CH:11][CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1.[N-:14]=[N+:15]=[N-:16].[Na+].O.ClCCl>CN(C)C=O>[N:14]([CH:2]1[C:8](=[O:9])[NH:7][C:6]2[N:10]=[CH:11][CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1)=[N+:15]=[N-:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 6344DichloromethaneHCID 33557Sodium AzideHCID 190670745,6,7,9-Tetrahydro-7-iodo-8H-pyrido[2,3-b]azepin-8-one

생성물 1

HCID 19067073HCID 19067073, 화합물수율 94.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
20 °C

실험 절차

To 333 mg of the intermediate obtained in Step G in 6 mL of dimethylformamide (DMF) was added 600 mg of sodium azide. The mixture was stirred at 20° C. 20 h before addition of water and extraction with dichloromethane. The extracts were combined and dried over sodium sulfate. Evaporation of the solvent gave 223 mg of the product characterized by its NMR and mass spectra.

후처리

  1. dry with materialdried over sodium sulfate
  2. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-9c8fea675a4c426d9124058290234526
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789587

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