Formaldehyde → 3-(4-Methoxyphenyl)-5,6-dihydroimidazo[1,5-c]quinazoline

HRID 481952

반응식

HRID 481952 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[NH2:20])[N:13]=2)=[CH:5][CH:4]=1.[CH2:21]=O>C(O)(=O)C.C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:13]3[CH2:21][NH:20][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[C:12]3=[CH:11][N:10]=2)=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 712FormaldehydeHCID 178488922HCID 178488922, 화합물

생성물 1

HCID 154787163-(4-Methoxyphenyl)-5,6-dihydroimidazo[1,5-c]quinazoline

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 8857Ethyl Acetate용매

실험 절차

2-(4-Methoxyphenyl)-4-(2-aminophenyl)imidazole (5 g) is dissolved in acetic acid (20 ml) and formaldehyde (37% in water, 1.53 ml) is added. The reaction is stirred for 2 min., diluted with ethyl acetate (100 ml), and extracted with 5%HCl (250 ml). The aqueous layer is basified with K2 CO3, then extracted with ethyl acetate. The organic layer is evaporated under reduced pressure and the residue is recrystallized from dichloromethane to afford 3-(4-methoxyphenyl)-5,6-dihydroimidazo[1,5-c]quinazoline (3 g) as a light brown solid. m.p. 190°-191° C.

후처리

  1. extractionextracted with 5%HCl (250 ml)
  2. extractionextracted with ethyl acetate
  3. customThe organic layer is evaporated under reduced pressure
  4. customthe residue is recrystallized from dichloromethane

출처 및 근거

ORD 기록
ord-1710ccb648c749e199ff16c13446b440
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05792766

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