Allylamine → HCID 178456990, 화합물

HRID 481968

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HRID 481968 반응식
O.CS[C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1.[CH2:16]([NH2:19])[CH:17]=[CH2:18]>>[CH2:16]([NH:19][C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1)[CH:17]=[CH2:18]

참가 물질

3

반응물 2

HCID 7853AllylamineHCID 190647513-Methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate

생성물 1

HCID 178456990HCID 178456990, 화합물

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온도
120 °C

실험 절차

A mixture of 3-methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate (0.5 g) and allylamine (4 mL) was heated in a sealed bumb for 4-5 h at 120° C. After cooling, the amine was removed by distillation under reduced pressure. The residue was dissolved in 0.5N NaOH, treated with charcoal, filtered, and the filtrate was adjusted to pH 6 with 1N HCl. The resulting precipitate was collected by filtration, washed with water and dried to give the title compound as a dihydrate (yield: 0.44 g); m.p. 206°-208° C. (Compound 15).

후처리

  1. temperatureAfter cooling
  2. customthe amine was removed by distillation under reduced pressure
  3. dissolutionThe residue was dissolved in 0.5N NaOH
  4. additiontreated with charcoal
  5. filtrationfiltered
  6. filtrationThe resulting precipitate was collected by filtration
  7. washwashed with water
  8. customdried

출처 및 근거

ORD 기록
ord-085a166e785e4f3b85065ec9ad85c7db
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05792764

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