2-Aminopropanol → HCID 178460116, 화합물

HRID 481970

반응식

HRID 481970 반응식
O.CS[C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1.[NH2:16][CH:17]([CH3:20])[CH2:18][OH:19]>C(OCC)C>[OH:19][CH2:18][CH:17]([NH:16][C:4]1[NH:9][C:8]2[CH:10]=[CH:11][N:12]=[CH:13][C:7]=2[S:6](=[O:15])(=[O:14])[N:5]=1)[CH3:20]

참가 물질

4

반응물 2

HCID 51262-AminopropanolHCID 190647513-Methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate

생성물 1

HCID 178460116HCID 178460116, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A suspension of 3-methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate and 2-amino-1-propanol (0.75 mL) was refluxed for 90 min (until completion of the reaction; t.l.c.). After cooling, the addition of diethylether (20 mL) gave rise to the separation of an oily residue. After decantation of the etheral solution, the residue was solubilized in methanol (1 mL) and then supplemented with diethylether (15 mL). An oily residue separated again. After decantation of the supernatent, the oily residue was solubilized in acetone (6 mL). A fine precipitate readily appeared. After 3 h at +4° C., the resulting precipitate was collected by filtration, washed with acetone and dried (yield: 0.33 g); m.p. 213°-216° C. (Compound 19).

후처리

  1. temperaturewas refluxed for 90 min (
  2. customuntil completion of the reaction
  3. temperatureAfter cooling
  4. customgave rise
  5. customto the separation of an oily residue
  6. customAn oily residue separated again
  7. filtrationthe resulting precipitate was collected by filtration
  8. washwashed with acetone
  9. customdried (yield: 0.33 g)

출처 및 근거

ORD 기록
ord-c0c6d6652c6e44438236c643e2c99a69
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05792764

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