Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → N-(1,2,3,4-tetrahydro-2-propyl-5-isoquinolinyl)-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 1-Iodopropane | HCID 33643 | — |
| 반응물 | 5-Nitroisoquinoline | HCID 69085 | — |
| 생성물 | N-(1,2,3,4-tetrahydro-2-propyl-5-isoquinolinyl)-acetamide | HCID 10376661 | — |
반응 단계
A solution of 5-nitroisoquinoline (25 g, 0.144 mol) and iodopropane (36.7 g, 0.216 mol) in 500 mL of EtOH was converted to the title compound by the procedures described in Example 1. The crude title compound was purified by chromatography (silica gel, 95:5 EtOAc:EtOH). The purified product was recrystallized from iPr2O/THF to give the title compound as a white solid (3.33 g, 18%), mp=123° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06703391B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-6b284eb5fb784751a6f68a70a1b7e4ac |
| 출처 메모 | uspto-grants-2004_03 |