Oxindole → 3-[(4-Methylthiophen-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one

HRID 482029노트

반응식

HRID 482029 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH3:11][C:12]1[CH:13]=[C:14]([CH:17]=O)[S:15][CH:16]=1>N1CCCCC1.C(O)C>[CH3:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][C:2]2=[O:10])[S:15][CH:16]=1

참가 물질

5

반응물 2

HCID 321710OxindoleHCID 27955264-methylthiophene-2-carbaldehyde

생성물 1

HCID 696317043-[(4-Methylthiophen-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one수율 61.1%

시약·촉매·용매 2

HCID 8082Piperidine촉매HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

A reaction mixture of 133.0 mg of oxindole, 151.2 mg of the 4-methylthiophene-2-carboxaldehyde, and 3 drops of piperidine in 3 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 147.3 mg (61%) of the title compound as a yellow solid.

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered
  3. washwashed with cold ethanol
  4. customdried

출처 및 근거

ORD 기록
ord-8a9e9512ad334afb98832c9bec13c9c7
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05792783

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