Ammonium Hydroxide → 8-Bromo-1,2,3,4-tetrahydro-2-methyl-6-nitro-5-isoquinolinamine
반응식
[Br:1][C:2]1[CH:3]=[C:4]([N+:17]([O-:19])=[O:18])[C:5]([NH:13]C(=O)C)=[C:6]2[C:11]=1[CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2.[NH4+].[OH-]>O>[Br:1][C:2]1[C:11]2[CH2:10][N:9]([CH3:12])[CH2:8][CH2:7][C:6]=2[C:5]([NH2:13])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1참가 물질
4
실험 절차
A solution of the product from Example 7 (3.68 g, 11.2 mmol) and 80 mL of 3:2H2SO4:H2O was heated at 90° C. for 1 hour. The reaction mixture was cooled and poured onto ice, and the resulting solution was made basic with concentrated aqueous NH4OH solution. The solid that formed was collected by suction filtration and dried under vacuum to give the title compound as a yellow solid (3.17 g, 99%).
후처리
- temperatureThe reaction mixture was cooled
- additionpoured onto ice
- customThe solid that formed
- filtrationwas collected by suction filtration
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-cbb1d9bde2784addb419500705adbb72
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06703391B2
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