Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-1,2,4-Triazole → 1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-1-(2,4-difluorophenyl)ethanone | HCID 588083 | — |
| 반응물 | 4-(2,4-Difluorophenyl)thiazole | HCID 10750658 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 생성물 | 1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol | HCID 9910022 | — |
반응 단계
2-Chloro-2',4'-difluoroacetophenone is added to 4-(2,4-difluorophenyl)thiazole in the presence of n-butyllithium. After subjecting the reaction product to a post treatment, 1,2,4-triazole and sodium hydride are added thereto to obtain 1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05792781 |
| 출처 데이터셋 | uspto-grants-1998_08 |
| ORD ID | ord-6db0f2d706d34c488440dcc432a7b087 |
| 출처 메모 | uspto-grants-1998_08 |