8-Bromo-1,2,3,4-tetrahydro-6-nitro-2-propyl-5-isoquinolinamine → HCID 10058790, 화합물

HRID 48206노트

반응식

HRID 48206 반응식
Br[C:2]1[C:11]2[CH2:10][N:9]([CH2:12][CH2:13][CH3:14])[CH2:8][CH2:7][C:6]=2[C:5]([NH2:15])=[C:4]([N+:16]([O-])=O)[CH:3]=1>CO.[Pd]>[CH2:12]([N:9]1[CH2:8][CH2:7][C:6]2[C:11](=[CH:2][CH:3]=[C:4]([NH2:16])[C:5]=2[NH2:15])[CH2:10]1)[CH2:13][CH3:14]

참가 물질

4

반응물 1

HCID 104257568-Bromo-1,2,3,4-tetrahydro-6-nitro-2-propyl-5-isoquinolinamine

생성물 1

HCID 10058790HCID 10058790, 화합물수율 129.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of the product from Example 12 (1.50 g, 4.77 mmol) and 20% Pd on carbon (0.30 g) in 75 mL of MeOH was hydrogenated at room temperature and pressure for 24 hours. The reaction mixture was concentrated and the residue was suspended in iPr2O and collected by filtration to give the title compound as a yellow solid (1.27 g, 93%).

후처리

  1. customwas hydrogenated at room temperature
  2. concentrationThe reaction mixture was concentrated
  3. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-5ac0eb774d324534a4d251b21c2c0b90
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703391B2

반응 노트

불러오는 중…