Benzenesulfonic acid 3-benzyloxy-5-methylphenyl ester → Benzenesulfonic acid 3-hydroxy-5-methylphenyl ester

HRID 482113

반응식

HRID 482113 반응식
C([O:8][C:9]1[CH:10]=[C:11]([O:16][S:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:12]=[C:13]([CH3:15])[CH:14]=1)C1C=CC=CC=1>[Pd].C(O)C>[OH:8][C:9]1[CH:10]=[C:11]([O:16][S:17]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:12]=[C:13]([CH3:15])[CH:14]=1

참가 물질

4

반응물 1

HCID 54005214Benzenesulfonic acid 3-benzyloxy-5-methylphenyl ester

생성물 1

HCID 11054545Benzenesulfonic acid 3-hydroxy-5-methylphenyl ester수율 98.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of benzenesulfonic acid 3-benzyloxy-5-methylphenyl ester (532 mg, 1.5 mmol), as prepared in the preceding step, and 10% palladium on carbon (200 mg) in ethanol (20 mL) was hydrogenated (balloon) overnight. The catalyst was removed by filtering over diatomaceous earth and the filtrate was evaporated in vacuo to give the title compound as a colorless syrup (390 mg, 98%). 1H-NMR (300 MHz, CDCl3 /CD3OD) δ 2.19 (s, 3H), 6.27 (s, 1H), 6.54 (s, 1H), 6.66 (s 1H), 7.43 (m, 1H), 7.55 (t, 1H), 7.70 (t, 1H), 7.85 (m, 2H).

후처리

  1. custom(balloon) overnight
  2. customThe catalyst was removed
  3. filtrationby filtering over diatomaceous earth
  4. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-07fbf5c563664a749808f9942eb4a60d
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05792769

연결된 노트

불러오는 중…