Dimethylacetamide → 2,3,5,6-Tetrafluorobenzoic Acid
반응식
CN(C)C(=O)C.[F:7][C:8]1[C:16]([F:17])=[C:15](C(O)=O)[C:14]([F:21])=[C:13]([F:22])[C:9]=1[C:10]([OH:12])=[O:11]>O>[F:7][C:8]1[C:16]([F:17])=[CH:15][C:14]([F:21])=[C:13]([F:22])[C:9]=1[C:10]([OH:12])=[O:11]참가 물질
4
반응 조건
- 온도
- 20 °C
실험 절차
N,N-Dimethylacetamide (14.0 parts) and 2,3,5,6-tetrafluoroterephthalic acid (2.91 parts) was heated at 70° C. for 4 hours before cooling to 20° C. adding water (7 parts) and cooling to 5° C. The precipitated solid was collected by filtration and washed with cold water and dried, the aqueous filtrates were evaporated under vacuum and the resultant solids combined to give 2,3,5,6-tetrafluorobenzoic acid (98%). 1,2,4,5-tetrafluorobenzene (2%) was also formed.
후처리
- temperaturecooling to 5° C
- filtrationThe precipitated solid was collected by filtration
- washwashed with cold water
- customdried
- customthe aqueous filtrates were evaporated under vacuum
출처 및 근거
- ORD 기록
- ord-c0a4bb5b3740452caefe96c7cf33b70b
- 출처 데이터셋
- uspto-grants-1998_08
- 특허 번호
- US05792887
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