2-Butanamine, 2-methyl- → 1-(3,4-Dichlorophenyl)-2-(tert-amylamino)ethanol hydrochloride

HRID 482288노트

반응식

HRID 482288 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([OH:12])[CH2:10]Br)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:13][C:14]([NH2:18])([CH2:16][CH3:17])[CH3:15]>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([OH:12])[CH2:10][NH:18][C:14]([CH2:16][CH3:17])([CH3:15])[CH3:13])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 689862-Butanamine, 2-methyl-HCID 3441362-Bromo-1-(3,4-dichlorophenyl)ethanol

생성물 1

HCID 190639411-(3,4-Dichlorophenyl)-2-(tert-amylamino)ethanol hydrochloride수율 78%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

27 g (0.1 mol) of 1-(3,4-dichlorophenyl)-2-bromoethanol are added in the cold state to a solution of 37.5 g (50 ml) (0.43 mol) of 2-methyl-2-butylamine, 100 ml of ethanol and 0.5 g of KI. After 48 hours in contact at 20° C. and 3 hours under reflux, the mixture is filtered, the filtrate is evaporated under vacuum, the residue is taken up with ether and the organic phase is washed with water. 200 ml of N HCl are added, and the product is drained and washed with 20 ml of cold water and with ether. The hydrochloride (m.p.=184°-185° C.) is obtained in a 78% yield.

후처리

  1. temperature3 hours under reflux
  2. filtrationthe mixture is filtered
  3. customthe filtrate is evaporated under vacuum
  4. washthe organic phase is washed with water
  5. addition200 ml of N HCl are added
  6. washwashed with 20 ml of cold water and with ether

출처 및 근거

ORD 기록
ord-1241d34b6f0e4d53bdaf40758f3b2004
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05795915

반응 노트

불러오는 중…