[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]2[C:18]([N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[N:19][C:20]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[N:21][C:10]1=2.C(N(CC)CC)C>C(Cl)Cl.O>[CH3:1][S:2]([O:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]2[C:18]([N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[N:19][C:20]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[N:21][C:10]1=2)(=[O:4])=[O:3]A mixture of methanesulfonyl chloride (0.38 mL) in methylene chloride (20 mL) is added dropwise to a mixture of 9-(2-hydroxyethyl)-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole (VIII, EXAMPLE3, 1.05 g) and triethylamine (0.5 mL) in methylene chloride (25 mL). After a few minutes, the reaction mixture is diluted with water and extracted with methylene chloride. The organic layer is dried (sodium sulfate) and concentrated, to give the title compound.
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