[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester → HCID 20633122, 화합물

HRID 48234노트

반응식

HRID 48234 반응식
C([O:3][C:4](=O)[C:5]([N:7]([CH2:21][CH2:22][CH2:23][CH3:24])[C:8]1[C:17]([N+:18]([O-])=O)=[CH:16][CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][CH2:12][NH:13]2)=[O:6])C>C(O)(=O)C.[Pd]>[CH2:21]([N:7]1[C:8]2[C:9]3[CH2:10][CH2:11][CH2:12][NH:13][C:14]=3[CH:15]=[CH:16][C:17]=2[NH:18][C:4](=[O:3])[C:5]1=[O:6])[CH2:22][CH2:23][CH3:24]

참가 물질

4

반응물 1

HCID 53663592[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester

생성물 1

HCID 20633122HCID 20633122, 화합물수율 71%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

A solution of the product from Example 88 (0.63 g) in 75 mL of acetic acid was treated with 56 Pd/C (0.2 g) and shaken on a Parr apparatus under a hydrogen atmosphere (52 psi) for 12 hours. The catalyst was removed by filtration and the filtrate evaporated. The residue was washed with ether to give the title compound (0.35 g, 71% yield).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. washThe residue was washed with ether

출처 및 근거

ORD 기록
ord-7ef201be0f5a416b828d947e63f1f096
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703391B2

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