Ethyl chloroformate → HCID 178526847, 화합물

HRID 482540

반응식

HRID 482540 반응식
FC(F)(F)C1C=CC=CC=1N=C=S.FC(F)(F)C1C=CC=CC=1NC(=S)NN.ClC(OCC)=O.[OH:35][C:36]1[N:40]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[C:47]([F:50])([F:49])[F:48])[C:39]([SH:51])=[N:38][N:37]=1.Br[C:53]1[S:54][C:55]([N+:58]([O-:60])=[O:59])=[CH:56][N:57]=1>>[OH:35][C:36]1[N:40]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[C:47]([F:48])([F:50])[F:49])[C:39]([S:51][C:53]2[S:54][C:55]([N+:58]([O-:60])=[O:59])=[CH:56][N:57]=2)=[N:38][N:37]=1

참가 물질

6

반응물 5

HCID 10928Ethyl chloroformateHCID 182112-Bromo-5-nitrothiazoleHCID 7231873-Amino-1-(2-(trifluoromethyl)phenyl)thioureaHCID 7371622-(Trifluoromethyl)phenyl isothiocyanateHCID 178518949HCID 178518949, 화합물

생성물 1

HCID 178526847HCID 178526847, 화합물수율 25.8%

실험 절차

The title compound was prepared in a manner similar to that described in Example 5 starting with 2-(trifluoromethyl) phenyl isothiocyanate. The intermediate 4-[2-(trifluoromethyl)phenyl]-3-thiosemicarbazide (2.04 g) was treated with ethyl chloroformate (1.09 g) as in example 5. The reaction product 3-hydroxy-5-mercapto-4-[2-(trifluoromethyl)phenyl]-1,2,4-triazole (0.78 g) was reacted with 0.63 g of 2-bromo-5-nitrothiazole as in Example 5. Crystallization from ethanol and water gave 0.3 g of 3-hydroxy-5-[(5-nitrothiazol-2-yl)mercapto]-4-[2-(trifluoromethyl)phenyl]-1,2,4-triazole, a yellow solid, MP 183°-185° C.

후처리

  1. customThe title compound was prepared in a manner similar to
  2. customCrystallization from ethanol and water

출처 및 근거

ORD 기록
ord-89a99e69631c46bba55db86b738d02c9
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05798374

연결된 노트

불러오는 중…