Dimethylamine → HCID 429128, 화합물
반응식
[CH3:1][NH:2][CH3:3].Br[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)=[O:7]>C(Cl)Cl>[CH3:1][N:2]([CH3:3])[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)=[O:7]참가 물질
4
반응 조건
- 온도
- 20 °C
실험 절차
To 66 g (1460 mmole) of anhydrous dimethylamine in 200 ml of methylene chloride and cooled to -30° C. was added a solution of 155 g (664 mmole) of 2-bromo-4'-chloroacetophenone in 200 ml of methylene chloride. After the addition was complete the reaction was allowed to warm to 20° C. Concentration in vacuo, partitioning between diethyl ether and 1M aqueous sodium hydroxide, washing with brine, drying over anhydrous magnesium sulfate, and reconcentration in vacuo gives 130 g of the title compound, an oil.
후처리
- additionAfter the addition
- concentrationConcentration in vacuo
- custompartitioning between diethyl ether and 1M aqueous sodium hydroxide
- washwashing with brine
- dry with materialdrying over anhydrous magnesium sulfate, and reconcentration in vacuo
출처 및 근거
- ORD 기록
- ord-172186e2915047bcb86b9570439c7da8
- 출처 데이터셋
- uspto-grants-1998_08
- 특허 번호
- US05798311
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