Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Calcium Carbonate → 3-Chloropropyl (4-hydroxy-2-nitrophenyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Calcium Carbonate | HCID 10112 | — |
| 반응물 | Carbonochloridic acid, 3-chloropropyl ester | HCID 69399 | — |
| 반응물 | 4-Amino-3-Nitrophenol | HCID 3758882 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 3-Chloropropyl (4-hydroxy-2-nitrophenyl)carbamate | HCID 20244590 | — |
반응 단계
77 g (0.5 mole) of 3-nitro-4-aminophenol are dissolved in 200 ml of dimethoxy ethane, 27 g of calcium carbonate are added, and 80 g (0.51 mole) of γ-chloropropyl chloroformate are added dropwise at 70° C. After 1 hour, the reaction mixture is filtered hot and the filtrate is stirred into 700 ml of ice-water, after which 128 g (93%) of the desired compound precipitate. The melting point is 103°-105° C., and after recrystallisation from toluene is 106° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04575378 |
| 출처 데이터셋 | uspto-grants-1986_03 |
| ORD ID | ord-f7719ddf30034dadbe3f7e7ec4fec665 |
| 출처 메모 | uspto-grants-1986_03 |