Bromine → Ethanone, 2-bromo-1-[4-(methylthio)phenyl]-2-phenyl-

HRID 482912노트

반응식

HRID 482912 반응식
[C:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([S:16][CH3:17])=[CH:12][CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:18]Br>C(Cl)Cl.CCOCC>[Br:18][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:8]([C:10]1[CH:11]=[CH:12][C:13]([S:16][CH3:17])=[CH:14][CH:15]=1)=[O:9]

참가 물질

5

반응물 2

HCID 24408BromineHCID 27600881-(4-(methylthio)phenyl)-2-phenylethanone

생성물 1

HCID 11336208Ethanone, 2-bromo-1-[4-(methylthio)phenyl]-2-phenyl-수율 94.2%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매2회

실험 절차

To a suspension of 30 g (0.12 mole) of 2-phenyl-1-(4-methylthiophenyl)ethanone in 45 ml of methylene chloride and 450 ml of ether was added dropwise a solution of 20.8 g (0.13 mole) of bromine in 65 ml of methylene chloride. The reaction mixture decolorized and became slightly exothermic. After stirring an additional 30 minutes, the reaction mixture was concentrated under vacuum. The crystalline product was collected by filtration and washed with hexane to give 36.3 g (91.5%) of 2-bromo-2-phenyl-1-(4-methylthiophenyl)ethanone as an off-white solid, m.p. 101°-103°.

후처리

  1. concentrationthe reaction mixture was concentrated under vacuum
  2. filtrationThe crystalline product was collected by filtration
  3. washwashed with hexane

출처 및 근거

ORD 기록
ord-e728a761dbb645189b054173295207c2
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04576958

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