Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Ethyl 3-oxothiomorpholine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | 1,4-Tetrahydrothiazine-3-one | HCID 88402 | — |
| 반응물 | Lithium diisopropylamide | HCID 2724682 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Ethyl 3-oxothiomorpholine-2-carboxylate | HCID 12858120 | 80% |
반응 단계
A mixture of thiomorpholin-3-one (1 equivalent), tetrahydrofuran (5-40 parts), and lithium diisopropylamide (1-2 equivalents) is stirred at -10° to 50° C. for 1 to 3 hours. To this mixture is added ethyl chloroformate (1 to 2 equivalents). After 1 to 3 hours' stirring, the mixture is acidified with hydrochloric acid, concentrated, diluted with ethyl acetate, washed with water, dried, and concentrated to give 3-oxothiomorpholine-2-carboxylic acid ethyl ester in 80 to 90% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04578378 |
| 출처 데이터셋 | uspto-grants-1986_03 |
| ORD ID | ord-889881e554b3495c8d655e1a7038ac9b |
| 출처 메모 | uspto-grants-1986_03 |