3-Aminobenzoic Acid → 3-[(3-Ethoxyacryloyl)amino]benzoic acid

HRID 483150

반응식

HRID 483150 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:11]([O:13][CH:14]=[CH:15][C:16](Cl)=[O:17])[CH3:12]>CCOCC>[C:5]([C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][CH:8]=1)[NH:1][C:16](=[O:17])[CH:15]=[CH:14][O:13][CH2:11][CH3:12])([OH:7])=[O:6]

참가 물질

4

반응물 2

HCID 74193-Aminobenzoic AcidHCID 30144293-Ethoxy-2-propenoyl chloride

생성물 1

HCID 545354873-[(3-Ethoxyacryloyl)amino]benzoic acid

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

100 Grams of m-aminobenzoic acid was suspended in 1 liter of ether, then 44.6 g of β-ethoxyacrylyl chloride was added dropwise into the solution at a room temperature under stirring condition. This reaction mixture was kept at 40° C. for 5 hours, then the precipitate formed in the reaction mixture was collected by filtration. The crystals were washed with water three times, dried and recrystallized from methanol to obtain 60 g of m-carboxy-N-(β-ethoxyacryloyl)aniline in the form of colorless cotton-like crystals.

후처리

  1. customthe precipitate formed in the reaction mixture
  2. filtrationwas collected by filtration
  3. washThe crystals were washed with water three times
  4. customdried
  5. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-c9097c1091594a68afd2e5411c08ae4a
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04578381

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