Isopropanol → HCID 70456982, 화합물

HRID 483199노트

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HRID 483199 반응식
[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[NH2:13]/[C:14](/C)=[CH:15]\[C:16]([O:18][CH3:19])=[O:17].[C:21]([O:27][CH2:28][C:29]([CH3:41])([CH3:40])[CH2:30][N:31]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:32])(=[O:26])[CH2:22][C:23]([CH3:25])=O.[CH3:42]C(O)C>>[CH3:25][C:23]1([CH3:42])[CH:22]([C:21]([O:27][CH2:28][C:29]([CH3:41])([CH3:40])[CH2:30][N:31]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH3:32])=[O:26])[CH:5]([C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([Cl:1])[C:3]=2[N+:10]([O-:12])=[O:11])[C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][NH:13]1

참가 물질

5

반응물 4

HCID 3776IsopropanolHCID 643918Methyl 3-aminocrotonateHCID 101083403-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetateHCID 122489723-CHLORO-2-NITROBENZALDEHYDE

생성물 1

HCID 70456982HCID 70456982, 화합물

실험 절차

A mixture of 185 mg of 3-chloro-2-nitrobenzaldehyde, 118 mg of methyl 3-aminocrotonate and 292 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate in 1 ml of 2-propanol was refluxed for 12 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a method of column chromatography on silica gel to yield 337 mg of the desired compound (132).

후처리

  1. temperaturewas refluxed for 12 hours
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was purified by a method of column chromatography on silica gel

출처 및 근거

ORD 기록
ord-7c373083ce3d4fbb96d390ffc50abd9a
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04578395

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