Oxalyl chloride → HCID 54425176, 화합물

HRID 483311노트

반응식

HRID 483311 반응식
[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3]([Cl:13])=[O:4]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 2568962-fluoro-3-methylpentanoic acid

생성물 1

HCID 54425176HCID 54425176, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

Finally, to the compound (v) was added 10 ml of dichloromethane and then 15 ml of oxalic acid chloride dropwise with ice cooling. The reaction was carried out under reflux at 40° C. for 3 hours. The reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation, and the residues were purified by vacuum distillation. Thus there was obtained 2-fluoro-3-methylpentanoic acid chloride (vi), which has a boiling point of 58°-60° C. (at 20 mmHg).

후처리

  1. distillationThe reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation
  2. distillationthe residues were purified by vacuum distillation

출처 및 근거

ORD 기록
ord-da6bdb019bbd4e6081af3d78a728ff6c
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225105

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