참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| 반응물 | Dibutyltin oxide | HCID 61221 | — |
| 반응물 | Ethyl 1-methylpiperidine-2-carboxylate | HCID 566742 | — |
| 생성물 | 2-(N,N-dimethylamino)ethyl N-methylpipecolinate | HCID 23176012 | — |
반응 단계
A mixture of 85 g (0.5 mol) of ethyl 1-methylpipecolinate, 44.6 g (0.5 mol) of N,N-dimethylethanolamine and 0.82 g of dibutyltin oxide was heated at about 145° C. for 30 hours. The ethanol by-product was collected in a Dean-Stark trap. When the rate of ethanol evolution and amount of ethanol collected showed that the reaction was essentially complete, the reaction was heated at about 180° C. until ethanol evolution ceased. The liquid product was purified by distillation at reduced pressure to provide 2-(N,N-dimethylamino)ethyl N-methylpipecolinate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05225513 |
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| 출처 데이터셋 | uspto-grants-1993_07 |
|---|
| ORD ID | ord-6e74ee1cb88d4903a3fa856dd9a5d693 |
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| 출처 메모 | uspto-grants-1993_07 |
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