Water → N-(beta-n-butoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline

HRID 483482

반응식

HRID 483482 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH2:28]([O:32][CH:33]=[CH:34][C:35](Cl)=[O:36])[CH2:29][CH2:30][CH3:31].O>C(OC(C)C)(C)C>[CH2:28]([O:32][CH:33]=[CH:34][C:35]([N:14]([CH:11]1[CH2:10][CH2:9][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:13][CH2:12]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:36])[CH2:29][CH2:30][CH3:31]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 70865N-Phenyl-1-(phenylmethyl)-4-piperidinamineHCID 534397723-Butoxyprop-2-enoyl chloride

생성물 1

HCID 54210636N-(beta-n-butoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline수율 98%

시약·촉매·용매 1

HCID 7914Diisopropyl Ether용매2회

반응 조건

온도
70 °C

실험 절차

To a mixture of N-(1-benzyl-4-piperidinyl)aniline (1.8 g), diisopropyl ether (20 ml) and triethylamine (0.87 g) is added dropwise a solution of β-n-butoxyacrylic acid chloride (1.4 g) in diisopropyl ether (5 ml) with stirring and heating at 70° C. After completion of dropwise addition, the mixture is further stirred with heating at the same temperature for 0.5 hour. After cooling, water is added to the reaction mixture and the mixture is subjected to extraction with ethyl acetate. The extract is washed with water and dried over magnesium sulfate. The solvent is distilled off under reduced pressure and the resulting residue is purified by silica gel column chromatography to give N-(β-n-butoxyacryloyl)-N-(1-benzyl-4-piperidinyl)-aniline (2.6 g).

후처리

  1. additionAfter completion of dropwise addition
  2. stirringthe mixture is further stirred
  3. temperaturewith heating at the same temperature for 0.5 hour
  4. temperatureAfter cooling
  5. extractionthe mixture is subjected to extraction with ethyl acetate
  6. washThe extract is washed with water
  7. dry with materialdried over magnesium sulfate
  8. distillationThe solvent is distilled off under reduced pressure
  9. customthe resulting residue is purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-961a585b2cfe4d859a4bab81ab32d461
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225402

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