Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(alpha-methylcinnamoyl)-N-(1-benzyl-4-piperidinyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | N-Phenyl-1-(phenylmethyl)-4-piperidinamine | HCID 70865 | — |
| 반응물 | alpha-Methylcinnamoylchloride | HCID 230201 | — |
| 용매 | Diisopropyl Ether | HCID 7914 | — |
| 생성물 | N-(alpha-methylcinnamoyl)-N-(1-benzyl-4-piperidinyl)aniline | HCID 54264746 | 90.2% |
반응 단계
To a mixture of N-(1-benzyl-4-piperidinyl)aniline (6.4 g), diisopropyl ether (70 ml) and triethylamine (4.8 ml) is added at 70° C. a solution of α-methylcinnamoyl chloride (4.9 g) in diisopropyl ether (10 ml). After stirring at the same temperature for 30 minutes, water is added to the reaction solution and the mixture is extracted with ethyl acetate. The extract is concentrated by distilling off the solvent and to the resulting residue is added diethyl ether and the formed crystals are separated by filtration to give N-(α-methylcinnamoyl)-N-(1-benzyl-4-piperidinyl)aniline (8.9 g), m.p. 150°-152° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05225402 |
| 출처 데이터셋 | uspto-grants-1993_07 |
| ORD ID | ord-4d9f6a71c1634e9e84c3e79c2f9ee452 |
| 출처 메모 | uspto-grants-1993_07 |