참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Aminobenzyl alcohol | HCID 69331 | — |
| 반응물 | Benzoyl chloride, 4-(tetradecyloxy)- | HCID 9998158 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[4-(Hydroxymethyl)phenyl]-4-(tetradecyloxy)benzamide | HCID 10410958 | 67.6% |
반응 단계
To a mixture of 9.75 g of p-aminobenzyl alcohol and 19.27 g of pyridine in 230 ml of methylene chloride cooled to 0° C. is added over 35 minutes a solution of 21.5 g of 4-tetradecyloxybenzoyl chloride in 230 ml of methylene chloride. The mixture is stirred at room temperature for 2 hours and diluted with chloroform. The mixture is heated to dissolve insolubles, washed with hot water and hot dilute hydrochloric acid then dried. The mixture is filtered hot and the solvent evaporated to a residue which is crystallized from tetrahydrofuran:hexane to give 18.1 g of the desired product as a yellow powder, m.p. 140°-145° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05225425 |
|---|
| 출처 데이터셋 | uspto-grants-1993_07 |
|---|
| ORD ID | ord-b01f59e7f69e4eaa80050d4a4b3793de |
|---|
| 출처 메모 | uspto-grants-1993_07 |
|---|
