Imidazole → 1,3-Dihydro-1-[4-(1H-imidazol-1-yl)-2-butynyl]-3-methyl-2H-imidazol-2-one
반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Br[CH2:7][C:8]#[C:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]([CH3:16])[C:12]1=[O:17]>O1CCOCC1>[N:1]1([CH2:7][C:8]#[C:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]([CH3:16])[C:12]2=[O:17])[CH:5]=[CH:4][N:3]=[CH:2]1참가 물질
4
실험 절차
Imidazole (3.87 g, 0.057 mol) was added to a stirred solution of 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one (3.26 g, 0.014 mol) in dioxane (50 mL). After 18 hr the dioxane was evaporated and the residue was chromatographed on silica gel to give 2.4 g of product.
후처리
- customAfter 18 hr the dioxane was evaporated
- customthe residue was chromatographed on silica gel
출처 및 근거
- ORD 기록
- ord-3a4a367fc3824972ac27088d764cb2f4
- 출처 데이터셋
- uspto-grants-1993_07
- 특허 번호
- US05225567
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