Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → Boc-gly-pro-OH
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | N-(tert-Butyloxycarbonyl)glycine N-hydroxysuccinimide ester | HCID 76926 | — |
| 반응물 | L-Proline | HCID 145742 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Boc-gly-pro-OH | HCID 11673468 | — |
반응 단계
1.4 ml (11 mmol) of N-methylmorpholine are added to 1.15 g (10 mmol) of proline in 50 ml of DMF. The mixture is cooled with an ice bath, 3.06 g (10 mmol) of Boc-Gly-OSu are then added and the pH is adjusted to between 6 and 7 throughout the reaction (14 h) by successive additions of small amounts of N-methylmorpholine (this substance is used as a proton acceptor). The DMF is evaporated off and the evaporation residue is taken up with AcOEt; after precipitation in petroleum ether and then filtration, the expected product is collected.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05225532 |
| 출처 데이터셋 | uspto-grants-1993_07 |
| ORD ID | ord-46a95c7b3d8442cca33271779bfafde1 |
| 출처 메모 | uspto-grants-1993_07 |