2-Aminoindane → 4-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidine

HRID 48398

반응식

HRID 48398 반응식
Cl[C:2]1[C:3]2[C:10]([CH3:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1>C(O)C>[CH2:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:21][CH:13]1[NH:12][C:2]1[C:3]2[C:10]([CH3:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1

참가 물질

4

반응물 2

HCID 763102-AminoindaneHCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidine

생성물 1

HCID 99257354-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidine수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-chloro-5-methylthieno[2,3-d]pyrimidine (92 mg, 0.50 mmol) (see J. Pharm. Soc. JAPAN, 109, 464 (1989)) and 2-aminoindan (330 mg, 2.5 mmol) in dry ethanol (1 ml) were heated to reflux under an argon atmosphere for 40 minutes. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (hexane:ethyl acetate=5:1) to obtain the title compound (140 mg, 0.50 mmol) having the following physical properties:

후처리

  1. temperatureto reflux under an argon atmosphere for 40 minutes
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe residue obtained
  4. customwas purified by silica gel chromatography (hexane:ethyl acetate=5:1)

출처 및 근거

ORD 기록
ord-2dd1b64c46964b598edb3b42f0923799
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703421B1

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