Potassium Carbonate → 1-(Benzimidazol-2-yl)-4-aminomethylpiperidine

HRID 484057노트

반응식

HRID 484057 반응식
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

생성물 1

HCID 197495451-(Benzimidazol-2-yl)-4-aminomethylpiperidine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

45 g of 4-aminomethylpiperidine are placed 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

후처리

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

출처 및 근거

ORD 기록
ord-4657c9f99e1c4e2ea18372ccbc0a787b
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05229398

반응 노트

불러오는 중…