Acetic Acid → 2,6-Dihydroxyethylaminotoluene

HRID 484265노트

반응식

HRID 484265 반응식
ClCCON[C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][C:16](=O)NOCCCl)[C:10]=1[CH3:23])=O.[OH-:24].[K+].[C:26]([OH:29])(=O)C.[CH3:30]O>O>[OH:24][CH2:30][CH2:16][NH:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([NH:8][CH2:6][CH2:26][OH:29])[C:10]=1[CH3:23]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 19746917HCID 19746917, 화합물

생성물 1

HCID 101305242,6-Dihydroxyethylaminotoluene

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
75 °C

실험 절차

33.5 g of the 2,6-bis(β-chloroethoxycarbamoylamino)toluene obtained above under the 1st stage are initially introduced into the reaction vessel in 200 ml of water and 30 ml of methanol. The reaction mixture is heated to 75° C. and 70 g of 50% strength potassium hydroxide solution are added dropwise in the course of one hour. After the mixture has been subsequently stirred at 60° C. for 21/2 hours, the pH is brought to 8.0 with glacial acetic acid and the reaction mixture is cooled slowly. The product which has precipitated is filtered off with suction, washed with water, and dried at 50° C. in a vacuum cabinet.

후처리

  1. temperaturethe reaction mixture is cooled slowly
  2. customThe product which has precipitated
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried at 50° C. in a vacuum cabinet

출처 및 근거

ORD 기록
ord-bf71a19806ae4cf2853e2b718c4b1e1e
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05230710

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