참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Methyl 3-amino-2-thiophenecarboxylate | HCID 89652 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 178518030 | HCID 178518030 | — |
반응 단계
3-aminothiophene-2-carboxylic acid methylester (1.6 g, 10 mmol) was added to formamide (3.4 ml), and the mixture was stirred at 200° C. for 2 hours. The reaction mixture was returned to room temperature, and water was added thereto, which was extracted with chloroform. The solid obtained by distilling off the solvent under reduced pressure was washed with ethyl acetate to obtain 4-hydroxythieno[3,2-d]pyrimidine (60 mg, 0.39 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06703421B1 |
|---|
| 출처 데이터셋 | uspto-grants-2004_03 |
|---|
| ORD ID | ord-acd8ccb1d4e34ab0a44c61593a48bc0e |
|---|
| 출처 메모 | uspto-grants-2004_03 |
|---|
