Benzyl Alcohol → HCID 18370146, 화합물

HRID 484752노트

반응식

HRID 484752 반응식
[CH3:1][CH:2]([CH3:10])[CH2:3][CH2:4][C:5](=[O:9])[C:6]([OH:8])=[O:7].C1(N=C=NC2CCCCC2)CCCCC1.[CH2:26](O)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C(Cl)Cl>[CH3:1][CH:2]([CH3:10])[CH2:3][CH2:4][C:5](=[O:9])[C:6]([O:8][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:7]

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 10868DicyclohexylcarbodiimideHCID 1293965126395-06-2

생성물 1

HCID 18370146HCID 18370146, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
-15 °C

실험 절차

A solution of 5-methyl-2-oxohexanoic acid (0.288 g.) in methylene chloride (1 ml.) was added during 15 minutes to a stirred solution of dicyclohexylcarbodiimide (0.412 g.) and benzyl alcohol (0.432 g.) in methylene chloride (10 ml.) which was cooled to -15° C., and the mixture was stirred at that temperature for 1 hour, then at laboratory temperature for 30 minutes, and was then evaporated to dryness. Water (1 ml.), diethyl ether (2 ml.) and acetic acid (0.01 ml.) were added and the mixture was kept at laboratory temperature for 12 hours and then evaporated to dryness. The residue was purified by chromatography on a silica gel column using toluene as eluant and there was thus obtained benzyl 5-methyl-2-oxohexanoate as an oil.

후처리

  1. waitat laboratory temperature for 30 minutes
  2. customwas then evaporated to dryness
  3. additionWater (1 ml.), diethyl ether (2 ml.) and acetic acid (0.01 ml.) were added
  4. waitthe mixture was kept at laboratory temperature for 12 hours
  5. customevaporated to dryness
  6. customThe residue was purified by chromatography on a silica gel column

출처 및 근거

ORD 기록
ord-80e098dd023b4de6a0e2fa2858024579
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533656

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