N-(4-amino-3-methylphenyl)acetamide → 2-[(2-Methyl-4-acetamidophenyl)amino]-1-pyrroline

HRID 484803

반응식

HRID 484803 반응식
[CH3:1][C:2]1[CH:8]=[C:7]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:5][C:3]=1[NH2:4].Cl[C:14]1[CH2:18][CH2:17][CH2:16][N:15]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:8]=[C:7]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:5][C:3]=1[NH:4][C:14]1[CH2:18][CH2:17][CH2:16][N:15]=1

참가 물질

4

반응물 2

HCID 838509N-(4-amino-3-methylphenyl)acetamideHCID 135201412-Chloro-1-pyrroline

생성물 1

HCID 202723882-[(2-Methyl-4-acetamidophenyl)amino]-1-pyrroline

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

The product aniline of Example 32 was added to a solution of 2-chloro-1-pyrroline, prepared by the method of Example 1 using toluene, and the mixture was stirred for four hours at reflux. The solvent was removed by decanting and the residual solid was dissolved in water. The acidic solution (ca. pH 1.5) was washed with ethyl acetate and then made strongly basic (ca. pH 13) with aqueous sodium hydroxide. The crude product compound was immediately extracted into ethyl acetate. The extract was filtered and concentrated in vacuo to an oil, which solidified on standing. The solid was triturated with diethyl ether, collected, and dried under vacuum to give the title compound, the free base of the compound prepared by the methods of Example 16 and 17. Structure assignment was supported by the nmr spectrum and by elemental analysis.

후처리

  1. temperatureat reflux
  2. customThe solvent was removed
  3. customby decanting
  4. dissolutionthe residual solid was dissolved in water
  5. washThe acidic solution (ca. pH 1.5) was washed with ethyl acetate
  6. extractionThe crude product compound was immediately extracted into ethyl acetate
  7. filtrationThe extract was filtered
  8. concentrationconcentrated in vacuo to an oil, which
  9. customThe solid was triturated with diethyl ether
  10. customcollected
  11. customdried under vacuum

출처 및 근거

ORD 기록
ord-2d7e70f7512f4a0887b18b31b7902053
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533739

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