1,8-Octanediamine, 4-(aminomethyl)- → 1,8-Bis(N-[2,4-bis(2,2,6,6-tetramethylpiperid-4-ylamino)-1,3,5-triazin-6-yl]amino)-4-(N-[2,4-bis(2,2,6,6-tetramethylpiperid-4-ylamino)-1,3,5-triazin-6-yl]aminomethyl)octane

HRID 484947노트

반응식

HRID 484947 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:5]=[C:4]([NH:19][CH:20]2[CH2:25][C:24]([CH3:27])([CH3:26])[NH:23][C:22]([CH3:29])([CH3:28])[CH2:21]2)[N:3]=1.[NH2:30][CH2:31][CH2:32][CH2:33][CH:34]([CH2:40][NH2:41])[CH2:35][CH2:36][CH2:37][CH2:38][NH2:39]>O>[CH3:28][C:22]1([CH3:29])[CH2:21][CH:20]([NH:19][C:4]2[N:5]=[C:6]([NH:8][CH:9]3[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]3)[N:7]=[C:2]([NH:30][CH2:31][CH2:32][CH2:33][CH:34]([CH2:40][NH:41][C:2]3[N:7]=[C:6]([NH:8][CH:9]4[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:17])([CH3:18])[CH2:10]4)[N:5]=[C:4]([NH:19][CH:20]4[CH2:25][C:24]([CH3:26])([CH3:27])[NH:23][C:22]([CH3:28])([CH3:29])[CH2:21]4)[N:3]=3)[CH2:35][CH2:36][CH2:37][CH2:38][NH:39][C:2]3[N:3]=[C:4]([NH:19][CH:20]4[CH2:25][C:24]([CH3:27])([CH3:26])[NH:23][C:22]([CH3:29])([CH3:28])[CH2:21]4)[N:5]=[C:6]([NH:8][CH:9]4[CH2:10][C:11]([CH3:18])([CH3:17])[NH:12][C:13]([CH3:16])([CH3:15])[CH2:14]4)[N:7]=3)[N:3]=2)[CH2:25][C:24]([CH3:27])([CH3:26])[NH:23]1

참가 물질

4

반응물 2

HCID 942111,8-Octanediamine, 4-(aminomethyl)-HCID 214680172-Chloro-4,6-bis(2,2,6,6-tetramethyl-4-piperidylamino)-1,3,5-triazine

생성물 1

HCID 202721371,8-Bis(N-[2,4-bis(2,2,6,6-tetramethylpiperid-4-ylamino)-1,3,5-triazin-6-yl]amino)-4-(N-[2,4-bis(2,2,6,6-tetramethylpiperid-4-ylamino)-1,3,5-triazin-6-yl]aminomethyl)octane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

5.1 g of 2-chloro-4,6-bis[N-(2,2,6,6-tetramethyl-4-piperidyl)amino]-1,3,5-triazine [prepared as described in Preparation 9(b)] were reacted with 0.7 g of 1,8-diamino-4-aminomethyloctane, following the procedure described in Example 9. After completion of the reaction, the reaction mixture was poured into water and extracted with chloroform. The extract was dried over anhydrous potassium carbonate, and the solvent was distilled off. The residue was purified by column chromatography through silica gel, eluted with a 8:2:1 by volume mixture of ethyl acetate, ethanol and triethylamine, to give the desired Compound No. 1 in the form of crystals melting at 148°-158° C.

후처리

  1. customAfter completion of the reaction
  2. extractionextracted with chloroform
  3. dry with materialThe extract was dried over anhydrous potassium carbonate
  4. distillationthe solvent was distilled off
  5. customThe residue was purified by column chromatography through silica gel
  6. washeluted with a 8:2:1 by volume mixture of ethyl acetate, ethanol and triethylamine

출처 및 근거

ORD 기록
ord-1ea1e17b3bb245cf80c2b46ec1cd01fe
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533688

반응 노트

불러오는 중…