4-Fluorobenzoyl chloride → 4-Fluoro-N-(4-methyl-2-oxopentyl)benzamide

HRID 485025노트

반응식

HRID 485025 반응식
Cl.[C:2]([CH2:8][NH2:9])(=[O:7])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)(O)[O-].[Na+].[F:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH:9][CH2:8][C:2](=[O:7])[CH2:3][CH:4]([CH3:6])[CH3:5])=[O:21])=[CH:18][CH:17]=1

참가 물질

4

반응물 3

HCID 678794-Fluorobenzoyl chlorideHCID 516892Sodium BicarbonateHCID 137017551-Amino-4-methylpentan-2-one hydrochloride

생성물 1

HCID 134903084-Fluoro-N-(4-methyl-2-oxopentyl)benzamide수율 93%

실험 절차

2.75 g of isovalerylmethylamine hydrochloride, 3.8 g of sodium bicarbonate and 3.16 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(4). 4.0 g of N-(4-fluorobenzoyl)isovalerylmethylamine are thereby obtained. Yield: 82.9%.

후처리

  1. customas described in Preparation 1-(4)

출처 및 근거

ORD 기록
ord-f02114539136430da32867c9d46a0e75
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04535089

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