HCID 13344846, 화합물 → HCID 20271324, 화합물
반응식
[CH3:1][N:2]([CH2:10][C:11]#[CH:12])[C:3]1[S:4][CH:5]=[C:6]([CH2:8][OH:9])[N:7]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]([CH2:10][C:11]#[CH:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]=[O:9])[N:7]=1참가 물질
4
실험 절차
2-(N-Methyl-2-propynylamino)-4-hydroxymethylthiazole (i) (4.36 g) was dissolved in methylene chloride (20 ml) and manganese dioxide (10 g) was added thereto. The mixture was stirred at room temperature for 16 hours and filtered off. The filtrate was evaporated and the residue was applied to column chromatography on silica gel (50 g) to give 2-(N-methyl-2-propynylamino)-4-formylthiazole (j) (2.56 g, yield 59%) from chloroform-ether (3:1) eluate as an oil.
후처리
- filtrationfiltered off
- customThe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-c0aff894581e42c392197d507f3ccd35
- 출처 데이터셋
- uspto-grants-1985_08
- 특허 번호
- US04535088
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