p-(p-Chlorocinnamamido)benzoic acid, ethyl ester → HCID 13503432, 화합물

HRID 485248노트

반응식

HRID 485248 반응식
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH:6]=[CH:7][C:8]([NH:10][C:11]2[CH:21]=[CH:20][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=2)=[O:9])=[CH:4][CH:3]=1.[H][H]>[Pd].O1CCCC1>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][CH2:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:20][CH:21]=2)=[O:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 692488p-(p-Chlorocinnamamido)benzoic acid, ethyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13503432HCID 13503432, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 30.0 g. of 4-(p-chlorocinnamamido)benzoic acid, ethyl ester, 500 mg. of 10% palladium on carbon, and 150 ml. of tetrahydrofuran is hydrogenated in a Parr apparatus, over a 2 hour period, repressurizing until hydrogen uptake is complete. The mixture is filtered, and the filtrate is evaporated. The solid is crystallized from 175 ml. of ethanol, giving 26.8 g. of the desired product as white crystals, m.p. 163°-165° C.

후처리

  1. additionA mixture of 30.0 g
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated
  4. customThe solid is crystallized from 175 ml
  5. customof ethanol, giving 26.8 g

출처 및 근거

ORD 기록
ord-3faf2a09773d453fb8666c6fc6dcaa3f
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536346

반응 노트

불러오는 중…