Phosgene → 2,3-Dihydro-1H-pyrrolizine-5-carbonyl chloride

HRID 485367노트

반응식

HRID 485367 반응식
[C:1]([Cl:4])(Cl)=[O:2].[CH2:5]1[C:12]2[N:8]([CH:9]=[CH:10][CH:11]=2)[CH2:7][CH2:6]1>C1(C)C=CC=CC=1.CCOCC>[CH2:11]1[C:12]2[N:8]([C:7]([C:1]([Cl:4])=[O:2])=[CH:6][CH:5]=2)[CH2:9][CH2:10]1

참가 물질

5

반응물 2

HCID 6371PhosgeneHCID 2593612,3-Dihydro-1H-pyrrolizine

생성물 1

HCID 134904052,3-Dihydro-1H-pyrrolizine-5-carbonyl chloride

시약·촉매·용매 2

HCID 1140Toluene용매HCID 3283Diethyl Ether용매

실험 절차

To a stirred, ice-bath cooled portion (30 ml) of 12.5% phosgene in toluene was added a solution of 2,3-dihydro-1H-pyrrolizine (0.80 g, 0.0074 m) in ether (30 ml) dropwise over ca two minutes. After stirring cold for ca 2.5 hr, the reaction mixture is allowed to warm to room temperature, the volatiles are removed in vacuo, and the resultant crystalline 2,3-dihydro-1H-pyrrolizine-5-carbonyl chloride used as is in the next step.

후처리

  1. customthe volatiles are removed in vacuo

출처 및 근거

ORD 기록
ord-c810a1ac01334986988088ce79433d35
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536512

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