2-Amino-4-methoxy-6-methyl-1,3,5-triazine → N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-(2-chloroethoxycarbonyl)benzenesulfonamide

HRID 485514

반응식

HRID 485514 반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([CH3:10])[N:3]=1.[Cl:11][CH2:12][CH2:13][O:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([N:26]=[C:27]=[O:28])(=[O:25])=[O:24])=[O:16]>C(Cl)Cl>[CH3:9][O:8][C:6]1[N:5]=[C:4]([CH3:10])[N:3]=[C:2]([NH:1][C:27]([NH:26][S:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[C:15]([O:14][CH2:13][CH2:12][Cl:11])=[O:16])(=[O:24])=[O:25])=[O:28])[N:7]=1

참가 물질

4

반응물 2

HCID 154662-Amino-4-methoxy-6-methyl-1,3,5-triazineHCID 139205492-(beta-Chloroethoxycarbonyl)benzenesulfonylisocyanate

생성물 1

HCID 13176696N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-(2-chloroethoxycarbonyl)benzenesulfonamide수율 80.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 0.7 g of 2-amino-4-methoxy-6-methyl-1,3,5-triazine in 10 ml anhydrous methylene chloride solvent was added 1.45 g 2-(β-chloroethoxycarbonyl)benzenesulfonyl isocyanate with stirring at ambient temperature. The mixture was thereafter stirred for sixteen hours. The solvent was evaporated under reduced pressure and the residue triturated with hexane and filtered to yield 1.72 g of compound which melted at 167°-170° C. The solid showed infrared absorption peaks at 1700 and 1705 cm-1, consistent for N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-(2-chloroethoxycarbonyl)benzenesulfonamide.

후처리

  1. stirringThe mixture was thereafter stirred for sixteen hours
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue triturated with hexane
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-72e4de42911b4b32bfe7563ff02b5d0d
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536576

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