Water → 2-Ethyl-[1,1'-biphenyl]-3-methanol

HRID 485553노트

반응식

HRID 485553 반응식
[CH2:1]([C:3]1[C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2].O>O1CCCC1.C(Cl)Cl>[CH2:1]([C:3]1[C:8]([CH2:9][OH:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 962WaterHCID 202706372-Ethyl-[1,1'-biphenyl]-3-carboxylic acid

생성물 1

HCID 202706032-Ethyl-[1,1'-biphenyl]-3-methanol수율 106.4%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 2-ethyl-[1,1'-biphenyl]-3-carboxylic acid (2.1 g, 0.0093 mole) in 50 ml of tetrahydrofuran was added dropwise borane-tetrahydrofuran complex (1.6 g, 0.0186 mole). The reaction mixture was stirred at room temperature for approximately 18 hours. Water (6 ml) was slowly added to the reaction mixture and the solvent removed under reduced pressure to give a residue. The residue was dissolved in methylene chloride; the solution was washed with 1N aqueous sodium hydroxide, dried over anhydrous magnesium sulfate, and filtered. The filtrate was evaporated under reduced pressure to give 2-ethyl-[1,1'-biphenyl]-3-methanol (2.1 g) as an oil. The ir and nmr spectra were consistent with the named compound.

후처리

  1. customthe solvent removed under reduced pressure
  2. customto give a residue
  3. washthe solution was washed with 1N aqueous sodium hydroxide
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-2660d9d3e4824cb9ac094d345bcd29eb
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536591

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