2-Thiophenecarboxaldehyde → Thien-2-yl-hydroxyacetonitrile

HRID 485615

반응식

HRID 485615 반응식
[CH:1]([C:3]1[S:4][CH:5]=[CH:6][CH:7]=1)=[O:2].[C-:8]#[N:9].[Na+].[O-]S([O-])=O.[Na+]>O>[S:4]1[CH:5]=[CH:6][CH:7]=[C:3]1[CH:1]([OH:2])[C:8]#[N:9]

참가 물질

5

반응물 3

HCID 73642-ThiophenecarboxaldehydeHCID 8929Sodium CyanideHCID 6399220CID 63992202회

생성물 1

HCID 11469116Thien-2-yl-hydroxyacetonitrile수율 59.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In this example 25.0 g of 2-formylthiophene was added to a stirred solution containing 10.93 g of sodium cyanide in 37 ml of water at room temperature. 63 ml of aqueous saturated sodium acid sulfite was then slowly added to the stirred mixture. During the addition of the sodium acid sulfite solution, small amounts (about 20 g) of ice were periodically added. The mixture was then stirred for another 15 minutes and extracted with ethyl ether. The ethyl ether extracts were combined, dried over magnesium sulfate and evaporated under vacuum affording 18.4 g of the title compound.

후처리

  1. additionwere periodically added
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-dc8afed6f1e6470da0a6400d0a8f8159
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04537623

연결된 노트

불러오는 중…