Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Nandrolone Decanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Decanoic Acid | HCID 2969 | — |
| 반응물 | Nandrolone | HCID 9904 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Methanol--water (1/1) | HCID 22242641 | — |
| 생성물 | Nandrolone Decanoate | HCID 9677 | 88.8% |
반응 단계
To a stirred solution of 5,48 g 19-nortestosterone, 4 g decanoic acid, 0.24 g DMAP and 0.19 g pTSA in 35 ml CH2Cl2 is slowly added at 10° C. a solution of 5.6 g DCC in 30 ml CH2Cl2. After 5 h at room temperature 2 ml acetic acid is added. The same work-up procedure as in Example 6 gives 7.6 g of pure 19-nortestosterone decanoate (88% yield) as white crystals from methanol/water. M.P. 35°-36° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04537722 |
| 출처 데이터셋 | uspto-grants-1985_08 |
| ORD ID | ord-a747324c27494f3e9207531db3365d42 |
| 출처 메모 | uspto-grants-1985_08 |