Methanol → Methyl alpha-methylbenzeneacetate
반응식
[C:1]1([CH:7]([CH3:11])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12]O>OS(O)(=O)=O>[C:1]1([CH:7]([CH3:11])[C:8]([O:10][CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
4
실험 절차
2-Phenylpropionic acid (8.4 g, 56 mmol) in methanol (180 ml) and concentrated H2SO4 (2 ml) were heated at reflux for 4 hours. The reaction was cooled down to room temperature and concentrated in vacuo (~30 ml), which was poured into ice water (~100 ml). The products were extracted with Et2O (150 ml×3), which was washed with saturated NaHCO3, H2O and dried over MgSO4. Filtration and evaporation of solvent yielded a yellow oil (8.9 g), which was distilled to give a colorless oil (8.34 g, 51 mmol, 91%, b.p. 73° C./1.5 mm Hg).
후처리
- temperatureat reflux for 4 hours
- concentrationconcentrated in vacuo (~30 ml), which
- additionwas poured into ice water (~100 ml)
- extractionThe products were extracted with Et2O (150 ml×3), which
- washwas washed with saturated NaHCO3, H2O
- dry with materialdried over MgSO4
- filtrationFiltration and evaporation of solvent
출처 및 근거
- ORD 기록
- ord-0d3b35d85a5f49b094e7fa4508bc28d3
- 출처 데이터셋
- uspto-grants-1985_08
- 특허 번호
- US04537904
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