HCID 178482203, 화합물 → HCID 178482196, 화합물

HRID 485753노트

반응식

HRID 485753 반응식
[CH3:1][NH:2][C:3]1[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][C:4]=1[C:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([OH:16])=[N:8]1)=[O:6]>CCO.[Pd]>[CH3:1][NH:2][C:3]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][C:4]=1[C:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([OH:16])=[N:8]1)=[O:6]

참가 물질

4

반응물 1

HCID 178482203HCID 178482203, 화합물

생성물 1

HCID 178482196HCID 178482196, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To 1.1 g. of 1-(2-methylamino-5-nitrobenzoyl)-1H-indazol-3-ol, prepared in Example 14, suspended in 200 ml of absolute EtOH was added 200 mg of 5% Pd/C and the mixture was hydrogenated at 50 psi for 16 hours. The catalyst was filtered off, washed with hot EtOH and the filtrate was diluted with H2O and concentrated to small volume. The precipitate was collected, washed with cold 95% EtOH and dried; yield of dark-yellow amorphous powder 0.65 g. (65.4%); m.p. 184°-186° C.

후처리

  1. filtrationThe catalyst was filtered off
  2. washwashed with hot EtOH
  3. additionthe filtrate was diluted with H2O
  4. concentrationconcentrated to small volume
  5. customThe precipitate was collected
  6. washwashed with cold 95% EtOH
  7. customdried

출처 및 근거

ORD 기록
ord-2e1ea073a0d54675ae6a193630976836
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04537966

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