Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Putrescine → 4,5,6,7-tetrahydro-2[2-(4-pyridyl)ethyl]-1H-1,3-diazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Putrescine | HCID 1045 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | 4-Pyridinepropanenitrile | HCID 7330461 | — |
| 반응물 | 1,4-Diaminobutane di-p-toluenesulfonate | HCID 20239771 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4,5,6,7-tetrahydro-2[2-(4-pyridyl)ethyl]-1H-1,3-diazepine | HCID 13281194 | 93.6% |
반응 단계
The mixture of 4-[2-cyanoethyl]pyridine (1.32 g, 0.01M), 1,4-diaminobutane (0.88 g, 0.01M) and 1,4-diaminobutane di-p-toluenesulfonate (4.32 g, 0.01M) was heated at about 190° to about 200° C. for 4 hrs. The residue was stirred with ethanol (20 ml) which contained EtONa (0.02M) and filtered. The filtrate was concentrated and distilled at 0.07 mmHg and a temperature of about 180° to about 200° C. to give 4,5,6,7-tetrahydro-2[2-(4-pyridyl)ethyl]-1H-1,3-diazepine (1.9 g, 93% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04537969 |
| 출처 데이터셋 | uspto-grants-1985_08 |
| ORD ID | ord-00ad8bcdb17a497f95b49814e74540b3 |
| 출처 메모 | uspto-grants-1985_08 |